Representative Publications

  1. Qin Q, Qu J, Yin Y, Liang Y, Wang Y, Xie B, Liu Q, Wang X, Xia X, Wang M, Zhang X, Jia J, Xing Y*, Li C*, Tang Y*. Unsupervised machine learning model to predict cognitive impairment in subcortical ischemic vascular disease. Alzheimers Dement. 2023.
  2. Jia J*, Zhao T, Liu Z, Liang Y, Li F, Li Y, Liu W, Li F, Shi S, Zhou C, Yang H, Liao Z, Li Y, Zhao H, Zhang J, Zhang K, Kan M, Yang S, Li H, Liu Z, Ma R, Lv J, Wang Y, Yan X, Liang F, Yuan X, Zhang J, Gauthier S, Cummings J. Association between healthy lifestyle and memory decline in older adults: 10 year, population based, prospective cohort study. BMJ. 2023;380:e072691.
  3. Wang YY, Deng YS, Dai SK, Mi TW, Li RY, Liu PP, Liu C, He BD, He XC, Du HZ, Yang HC, Tang Y*, Liu CM*, Teng ZQ*. Loss of microglial EED impairs synapse density, learning, and memory. Mol Psychiatry. 2022;27(7):2999-3009.
  4. Wang C, Wang Z, Xie B, Shi X, Yang P, Liu L, Qu T, Qin Q, Xing Y, Zhu W, Teipel SJ, Jia J, Zhao G*, Li L*, Tang Y*. Binaural processing deficit and cognitive impairment in Alzheimer’s disease. Alzheimers Dement. 2022;18(6):1085-1099.
  5. Teipel S*, Gustafson D, Ossenkoppele R, Hansson O, Babiloni C, Wagner M, Riedel-Heller SG, Kilimann I, Tang Y. Alzheimer Disease: Standard of Diagnosis, Treatment, Care, and Prevention. J Nucl Med. 2022;63(7):981-985.
  6. Lutz MW, Khachaturian AS*, Zetterberg H, Blennow K, Willette AA, Mielke MM, Hayden KM, Dodge HH, Tang Y, Greenberg BD, Kukull WA, Khachaturian ZS. Biomarkers of Alzheimer syndrome and related dementias: A&D author’s guide. Alzheimers Dement. 2022;18(9):1595-1601.
  7. Liu W, Gauthier S, Jia J*. Alzheimer’s disease: current status and perspective. Sci Bull (Beijing). 2022;67(24):2494-2497.
  8. Liu PP, Dai SK, Mi TW, Tang GB, Wang Z, Wang H, Du HZ, Tang Y*, Teng ZQ*, Liu CM*. Acetate supplementation restores cognitive deficits caused by ARID1A haploinsufficiency in excitatory neurons. EMBO Mol Med. 2022;14(12):e15795.
  9. Jia L*, Zhu M, Yang J, Pang Y, Wang Q, Li T, Li F, Wang Q, Li Y, Wei Y. Exosomal MicroRNA-Based Predictive Model for Preclinical Alzheimer’s Disease: A Multicenter Study. Biol Psychiatry. 2022;92(1):44-53.
  10. Jia L*, Yang J, Zhu M, Pang Y, Wang Q, Wei Q, Li Y, Li T, Li F, Wang Q, Li Y, Wei Y. A metabolite panel that differentiates Alzheimer’s disease from other dementia types. Alzheimers Dement. 2022;18(7):1345-1356.
  11. Jia J*, Ning Y, Chen M, Wang S, Li Y, Yang H. Ending age discrimination and stigma to promote healthy ageing in China. Lancet. 2022;400(10367):1907-1909.
  12. Hampel H*, Shaw LM, Aisen P, Chen C, Lleo A, Iwatsubo T, Iwata A, Yamada M, Ikeuchi T, Jia J, Wang H, Teunissen CE, Peskind E, Blennow K, Cummings J, Vergallo A. State-of-the-art of lumbar puncture and its place in the journey of patients with Alzheimer’s disease. Alzheimers Dement. 2022;18(1):159-177.
  13. Zhang H, Wang Y, Lyu D, Li Y, Li W, Wang Q, Li Y, Qin Q, Wang X, Gong M, Jiao H, Liu W, Jia J*. Cerebral blood flow in mild cognitive impairment and Alzheimer’s disease: A systematic review and meta-analysis. Ageing Res Rev. 2021;71:101450.
  14. Jia L*, Zhu M, Yang J, Pang Y, Wang Q, Li Y, Li T, Li F, Wang Q, Li Y, Wei Y. Prediction of P-tau/Abeta42 in the cerebrospinal fluid with blood microRNAs in Alzheimer’s disease. BMC Med. 2021;19(1):264.
  15. Jia L, Zhu M, Kong C, Pang Y, Zhang H, Qiu Q, Wei C, Tang Y, Wang Q, Li Y, Li T, Li F, Wang Q, Li Y, Wei Y, Jia J*. Blood neuro-exosomal synaptic proteins predict Alzheimer’s disease at the asymptomatic stage. Alzheimers Dement. 2021;17(1):49-60.
  16. Jia L, Li F, Wei C, Zhu M, Qu Q, Qin W, Tang Y, Shen L, Wang Y, Shen L, Li H, Peng D, Tan L, Luo B, Guo Q, Tang M, Du Y, Zhang J, Zhang J, Lyu J, Li Y, Zhou A, Wang F, Chu C, Song H, Wu L, Zuo X, Han Y, Liang J, Wang Q, Jin H, Wang W, Lu Y, Li F, Zhou Y, Zhang W, Liao Z, Qiu Q, Li Y, Kong C, Li Y, Jiao H, Lu J*, Jia J*. Prediction of Alzheimer’s disease using multi-variants from a Chinese genome-wide association study. Brain. 2021;144(3):924-937.
  17. Chen C, Zhou Y, Wang H, Alam A, Kang SS, Ahn EH, Liu X, Jia J, Ye K*. Gut inflammation triggers C/EBPbeta/delta-secretase-dependent gut-to-brain propagation of Abeta and Tau fibrils in Alzheimer’s disease. EMBO J. 2021;40(17):e106320.
  18. Yu JT*, Xu W, Tan CC, Andrieu S, Suckling J, Evangelou E, Pan A, Zhang C, Jia J, Feng L, Kua EH, Wang YJ, Wang HF, Tan MS, Li JQ, Hou XH, Wan Y, Tan L, Mok V, Tan L, Dong Q, Touchon J, Gauthier S, Aisen PS, Vellas B. Evidence-based prevention of Alzheimer’s disease: systematic review and meta-analysis of 243 observational prospective studies and 153 randomised controlled trials. J Neurol Neurosurg Psychiatry. 2020;91(11):1201-1209.
  19. Mok VCT*, Pendlebury S, Wong A, Alladi S, Au L, Bath PM, Biessels GJ, Chen C, Cordonnier C, Dichgans M, Dominguez J, Gorelick PB, Kim S, Kwok T, Greenberg SM, Jia J, Kalaria R, Kivipelto M, Naegandran K, Lam LCW, Lam BYK, Lee ATC, Markus HS, O’Brien J, Pai MC, Pantoni L, Sachdev P, Skoog I, Smith EE, Srikanth V, Suh GH, Wardlaw J, Ko H, Black SE, Scheltens P. Tackling challenges in care of Alzheimer’s disease and other dementias amid the COVID-19 pandemic, now and in the future. Alzheimers Dement. 2020;16(11):1571-1581.
  20. Jia L, Xu H, Chen S, Wang X, Yang J, Gong M, Wei C, Tang Y, Qu Q, Chu L, Shen L, Zhou C, Wang Q, Zhao T, Zhou A, Li Y, Li F, Li Y, Jin H, Qin Q, Jiao H, Li Y, Zhang H, Lyu D, Shi Y, Song Y, Jia J*. The APOE epsilon4 exerts differential effects on familial and other subtypes of Alzheimer’s disease. Alzheimers Dement. 2020;16(12):1613-1623.
  21. Jia L, Quan M, Fu Y, Zhao T, Li Y, Wei C, Tang Y, Qin Q, Wang F, Qiao Y, Shi S, Wang YJ, Du Y, Zhang J, Zhang J, Luo B, Qu Q, Zhou C, Gauthier S, Jia J*, Group for the Project of Dementia Situation in C. Dementia in China: epidemiology, clinical management, and research advances. Lancet Neurol. 2020;19(1):81-92.
  22. Jia L, Fu Y, Shen L, Zhang H, Zhu M, Qiu Q, Wang Q, Yan X, Kong C, Hao J, Wei C, Tang Y, Qin W, Li Y, Wang F, Guo D, Zhou A, Zuo X, Yu Y, Li D, Zhao L, Jin H, Jia J*. PSEN1, PSEN2, and APP mutations in 404 Chinese pedigrees with familial Alzheimer’s disease. Alzheimers Dement. 2020;16(1):178-191.
  23. Jia L, Du Y, Chu L, Zhang Z, Li F, Lyu D, Li Y, Li Y, Zhu M, Jiao H, Song Y, Shi Y, Zhang H, Gong M, Wei C, Tang Y, Fang B, Guo D, Wang F, Zhou A, Chu C, Zuo X, Yu Y, Yuan Q, Wang W, Li F, Shi S, Yang H, Zhou C, Liao Z, Lv Y, Li Y, Kan M, Zhao H, Wang S, Yang S, Li H, Liu Z, Wang Q, Qin W, Jia J*, Group C. Prevalence, risk factors, and management of dementia and mild cognitive impairment in adults aged 60 years or older in China: a cross-sectional study. Lancet Public Health. 2020;5(12):e661-e671.
  24. Zhang J, Chen B, Lu J, Wu Y, Wang S, Yao Z, Zhu L, Qiao Y, Sun Q, Qin W, Zhao Q, Jia J, Wei C*. Brains of rhesus monkeys display Abeta deposits and glial pathology while lacking Abeta dimers and other Alzheimer’s pathologies. Aging Cell. 2019;18(4):e12978.
  25. Wu S, Wu B, Liu M, Chen Z, Wang W, Anderson CS, Sandercock P, Wang Y, Huang Y, Cui L, Pu C, Jia J, Zhang T, Liu X, Zhang S, Xie P, Fan D, Ji X, Wong KL, Wang L, China Stroke Study C. Stroke in China: advances and challenges in epidemiology, prevention, and management. Lancet Neurol. 2019;18(4):394-405.
  26. Wang W, Hou TT, Jia LF, Wu QQ, Quan MN, Jia JP*. Toxic amyloid-beta oligomers induced self-replication in astrocytes triggering neuronal injury. EBioMedicine. 2019;42:174-187.
  27. Tang Y, Xing Y, Zhu Z, He Y, Li F, Yang J, Liu Q, Li F, Teipel SJ, Zhao G, Jia J*. The effects of 7-week cognitive training in patients with vascular cognitive impairment, no dementia (the Cog-VACCINE study): A randomized controlled trial. Alzheimers Dement. 2019;15(5):605-614.
  28. Tang Y*, Lutz MW, Xing Y. A systems-based model of Alzheimer’s disease. Alzheimers Dement. 2019;15(1):168-171.
  29. Jia L, Qiu Q, Zhang H, Chu L, Du Y, Zhang J, Zhou C, Liang F, Shi S, Wang S, Qin W, Wang Q, Li F, Wang Q, Li Y, Shen L, Wei Y, Jia J*. Concordance between the assessment of Abeta42, T-tau, and P-T181-tau in peripheral blood neuronal-derived exosomes and cerebrospinal fluid. Alzheimers Dement. 2019;15(8):1071-1080.
  30. Wang ZH, Gong K, Liu X, Zhang Z, Sun X, Wei ZZ, Yu SP, Manfredsson FP, Sandoval IM, Johnson PF, Jia J*, Wang JZ*, Ye K*. C/EBPbeta regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer’s disease. Nat Commun. 2018;9(1):1784.
  31. Jia J*, Wei C, Chen S, Li F, Tang Y, Qin W, Zhao L, Jin H, Xu H, Wang F, Zhou A, Zuo X, Wu L, Han Y, Han Y, Huang L, Wang Q, Li D, Chu C, Shi L, Gong M, Du Y, Zhang J, Zhang J, Zhou C, Lv J, Lv Y, Xie H, Ji Y, Li F, Yu E, Luo B, Wang Y, Yang S, Qu Q, Guo Q, Liang F, Zhang J, Tan L, Shen L, Zhang K, Zhang J, Peng D, Tang M, Lv P, Fang B, Chu L, Jia L, Gauthier S. The cost of Alzheimer’s disease in China and re-estimation of costs worldwide. Alzheimers Dement. 2018;14(4):483-491.
  32. Jia J*, Gauthier S, Pallotta S, Ji Y, Wei W, Xiao S, Peng D, Guo Q, Wu L, Chen S, Kuang W, Zhang J, Wei C, Tang Y. Consensus-based recommendations for the management of rapid cognitive decline due to Alzheimer’s disease. Alzheimers Dement. 2017;13(5):592-597.
  33. Ikram MA*, Bersano A, Manso-Calderon R, Jia JP, Schmidt H, Middleton L, Nacmias B, Siddiqi S, Adams HH. Genetics of vascular dementia – review from the ICVD working group. BMC Med. 2017;15(1):48.
  34. Jia J*, Zuo X, Jia XF, Chu C, Wu L, Zhou A, Wei C, Tang Y, Li D, Qin W, Song H, Ma Q, Li J, Sun Y, Min B, Xue S, Xu E, Yuan Q, Wang M, Huang X, Fan C, Liu J, Ren Y, Jia Q, Wang Q, Jiao L, Xing Y, Wu X, China C, Aging Study G. Diagnosis and treatment of dementia in neurology outpatient departments of general hospitals in China. Alzheimers Dement. 2016;12(4):446-453.
  35. Jia J*, Wei C, Liang J, Zhou A, Zuo X, Song H, Wu L, Chen X, Chen S, Zhang J, Wu J, Wang K, Chu L, Peng D, Lv P, Guo H, Niu X, Chen Y, Dong W, Han X, Fang B, Peng M, Li D, Jia Q, Huang L. The effects of DL-3-n-butylphthalide in patients with vascular cognitive impairment without dementia caused by subcortical ischemic small vessel disease: A multicentre, randomized, double-blind, placebo-controlled trial. Alzheimers Dement. 2016;12(2):89-99.
  36. Zhang Z, Song M, Liu X, Su Kang S, Duong DM, Seyfried NT, Cao X, Cheng L, Sun YE, Ping Yu S, Jia J*, Levey AI*, Ye K*. Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer’s disease. Nat Commun. 2015;6:8762.
  37. Tang Y, Wang X, Jia J*. Mercury poisoning presenting as sporadic Creutzfeldt-Jakob disease: a case report. Ann Intern Med. 2015;162(6):462-463.
  38. Mei Y, Jiang C, Wan Y, Lv J, Jia J, Wang X, Yang X*, Tong Z*. Aging-associated formaldehyde-induced norepinephrine deficiency contributes to age-related memory decline. Aging Cell. 2015;14(4):659-668.
  39. Jia J*, Zhou A, Wei C, Jia X, Wang F, Li F, Wu X, Mok V, Gauthier S, Tang M, Chu L, Zhou Y, Zhou C, Cui Y, Wang Q, Wang W, Yin P, Hu N, Zuo X, Song H, Qin W, Wu L, Li D, Jia L, Song J, Han Y, Xing Y, Yang P, Li Y, Qiao Y, Tang Y, Lv J, Dong X. The prevalence of mild cognitive impairment and its etiological subtypes in elderly Chinese. Alzheimers Dement. 2014;10(4):439-447.
  40. Jia J*, Wang F, Wei C, Zhou A, Jia X, Li F, Tang M, Chu L, Zhou Y, Zhou C, Cui Y, Wang Q, Wang W, Yin P, Hu N, Zuo X, Song H, Qin W, Wu L, Li D, Jia L, Song J, Han Y, Xing Y, Yang P, Li Y, Qiao Y, Tang Y, Lv J, Dong X. The prevalence of dementia in urban and rural areas of China. Alzheimers Dement. 2014;10(1):1-9.
  41. Xing Y, Jia JP*, Ji XJ, Tian T. Estrogen associated gene polymorphisms and their interactions in the progress of Alzheimer’s disease. Prog Neurobiol. 2013;111:53-74.
  42. Wang Y*, Wang Y, Zhao X, Liu L, Wang D, Wang C, Wang C, Li H, Meng X, Cui L, Jia J, Dong Q, Xu A, Zeng J, Li Y, Wang Z, Xia H, Johnston SC, Investigators C. Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. N Engl J Med. 2013;369(1):11-19.
  43. Wang J, Zuo X, Dai Z, Xia M, Zhao Z, Zhao X, Jia J, Han Y, He Y*. Disrupted functional brain connectome in individuals at risk for Alzheimer’s disease. Biol Psychiatry. 2013;73(5):472-481.
  44. Leak RK, Zhang L, Luo Y, Li P, Zhao H, Liu X, Ling F, Jia J, Chen J, Ji X*. Peroxiredoxin 2 battles poly(ADP-ribose) polymerase 1- and p53-dependent prodeath pathways after ischemic injury. Stroke. 2013;44(4):1124-1134.
  45. Meng R, Asmaro K, Meng L, Liu Y, Ma C, Xi C, Li G, Ren C, Luo Y, Ling F, Jia J, Hua Y, Wang X, Ding Y, Lo EH, Ji X*. Upper limb ischemic preconditioning prevents recurrent stroke in intracranial arterial stenosis. Neurology. 2012;79(18):1853-1861.
  46. Shi FD, Jia JP*. Neurology and neurologic practice in China. Neurology. 2011;77(22):1986-1992.
  47. Qin W, Jia L, Zhou A, Zuo X, Cheng Z, Wang F, Shi F, Jia J*. The -980C/G polymorphism in APH-1A promoter confers risk of Alzheimer’s disease. Aging Cell. 2011;10(4):711-719.
  48. Tang Y, Wang X*, Ding Y, Li C, Jia J. Longitudinal lesion of the spinal cord in a patient with Vogt-Koyanagi-Harada disease. J Neurol Neurosurg Psychiatry. 2010;81(8):941-942.
  49. Zhou J*, Meng R, Sui X, Meng L, Jia J, Yang B. Effects of administration styles of arsenic trioxide on intracellular arsenic concentration, cell differentiation and apoptosis. Haematologica. 2005;90(9):1277-1279.
  50. Jia JM, Pollock M*, Jia JP. Cold injury to nerves is not due to ischaemia alone. Brain. 1998;121 ( Pt 5):989-1001.
  51. Jia J, Pollock M*. The pathogenesis of non-freezing cold nerve injury. Observations in the rat. Brain. 1997;120 ( Pt 4):631-646.